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Use of Surrogate Markers to Predict the HIV Disease Stage and Time to Initiate Antiretroviral Therapy in Developing Countries
* To whom correspondence should be addressed. E-mail: drmonica74{at}gmail.com.
 -2 microglobulin and total lymphocyte count (TLC) with CD4 counts for monitoring disease progression and identify patients who require ART. The authors measured CD4 T-cell counts, TLC, and -2 microglobulin levels in 119 HIV seropositive patients. There was a significant negative correlation between CD4 counts and -2 microglobulin levels and significant positive correlation between TLC and CD4 counts. Taking a TLC cutoff of  1600 and -2 microglobulin levels  3.5 mg/l, the authors could identify 90.4% of patients with CD4 count 200 cells/µl. These assays may allow reduction in the annual number of CD4 cell evaluation and the cost associated with monitoring the immune status of HIV-positive patients.
First published on September 9, 2008, doi:10.1177/1545109708322302 |
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