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Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma and Local Polymorphic B-Cell Lymphoproliferative Disorder in a Patient With HIV Disease

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy, Roberto.manfredi{at}unibo.it

Sergio Sabbatani, MD

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy

Umberto Gianelli, MD

Department of Pathology, DMCO University of Milan, S. Paolo Hospital and IRCCS Ospedale Maggiore Policlinico, Milan, Italy

Ginevra Marinacci, MD

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy

A rare case report of HIV-associated nasopharyngeal carcinoma concurrent with local polymorphic B-cell lymphoproliferative disorder is reported and discussed on the ground of the most recent literature evidences. Only very few reports of nasopharyngeal carcinoma have been described until now in patients infected with HIV (one case in adults), and a coexisting lymphoid cell proliferation with a concurrent role of Epstein-Barr virus in prompting both disorders was never reported to date. The relevant pathogenetic, diagnostic, and therapeutic questions raised by this infrequent intriguing association retrieved in a patient with prominent HIV-related immunodeficiency are focused on.

Key Words: nasopharyngeal carcinoma • lymphoproliferative disorder • Epstein-Bar virus • HIV • pathogenesis • diagnosis • management

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This version was published on December 1, 2007

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 6, No. 4, 255-259 (2007)
DOI: 10.1177/1545109707302070


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Manfredi, R. Articles by Marinacci, G. Search for Related Content PubMed PubMed Citation Articles by Manfredi, R. Articles by Marinacci, G. Social Bookmarking                         What's this?