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Steady-State Pharmacokinetics of Nevirapine in HIV-1 Infected Adults in India

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

A.K. Hemanthkumar, PhD

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

S. Rajasekaran, MD

Government Hospital of Thoracic Medicine, Tambaram, Chennai, India

C. Padmapriyadarsini, MBBS, MNAMS DNB

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

G. Narendran, DTRD, DNB

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

S. Anitha, PhD

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

Sudha Subramanyam, PhD

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

V. Kumaraswami, MD, PhD

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India

Soumya Swaminathan, MD, DNB

HIV/AIDS Division, Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India, doctorsoumya{at}yahoo.com

Background and Objectives: A variety of demographic factors, sex, and degree of immunosuppression can influence antiretroviral drug concentrations. The authors studied the influence of immune status, sex, and body mass index (BMI) on the steady-state pharmacokinetics of nevirapine delivered as a fixed-dose combination in HIV-1-infected patients in India. Methods: Twenty-six HIV-1-infected adult patients undergoing treatment with nevirapine-based highly active antiretroviral therapy regimens participated in the study. Pharmacokinetic variables were compared between patients divided based on CD4 cell counts, sex, and BMI. Results: Patients with higher BMI had lower peak and trough concentration and exposure of nevirapine than those with lower BMI; none of the differences in the pharmacokinetic variables of nevirapine between the various patient groups was statistically significant. Conclusions: Patients' immune status, sex, or BMI had no impact on the pharmacokinetics of nevirapine. Plasma nevirapine concentrations were maintained within the therapeutic range of the drug in the majority of the patients.

Key Words: pharmacokinetics • nevirapine • India • immune status • sex • BMI

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Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 6, No. 4, 251-254 (2007)
DOI: 10.1177/1545109707301344


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ramachandran, G. Articles by Swaminathan, S. Search for Related Content PubMed PubMed Citation Articles by Ramachandran, G. Articles by Swaminathan, S. Social Bookmarking                         What's this?