This Article Full Text (PDF) All Versions of this Article: 1545109709341855v1 8/5/286    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Coelho Lima, B. M. Articles by Espinosa Miranda, A. PubMed PubMed Citation Articles by Coelho Lima, B. M. Articles by Espinosa Miranda, A. Social Bookmarking                         What's this?

Human Papillomavirus in Women With and Without HIV-1 Infection Attending an STI Clinic in Vitoria, Brazil

Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil

Jonathan E. Golub, PhD

School of Medicine, Johns Hopkins University, Baltimore, Maryland

Adriana Tonani Mattos

Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil

Luciana Bueno de Freitas

Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil

Liliana Cruz Spano, PhD

Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil

Angélica Espinosa Miranda, MD, PhD

Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Brazil, espinosa{at}ndi.ufes.br

We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39.4%) HIV-positive women and 172 (60.5%) HIV-negative women. HPV-DNA was detected in 133 (46.8%). HIV-infected women were almost twice as likely to be concurrently infected with HPV than HIV-negative women (OR = 1.87 95% CI: 1.16-3.03). The high proportion of HPV detected among women attending an STI/AIDS clinic, particularly among HIV-infected women, proves the importance of screening this high-risk group in the hope of earlier detection and treatment of cervical intraepithelial neoplasia (CIN).

Key Words: human papillomavirus (HPV) • HIV • women • sexually transmitted infection (STI) clinic • cervical intraepitial neoplasia (CIN) • Brazil

This version was published on September 1, 2009

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 8, No. 5, 286-290 (2009)
DOI: 10.1177/1545109709341855


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?