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Journal of the International Association of Physicians in AIDS Care (JIAPAC)
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Immune Reconstitution Visceral Leishmaniasis Presented as Hemophagocytic Syndrome in a Patient With AIDS From a Nonendemic Area: A Case Report

Ketan K. Patel, MD

Infectious Diseases Clinic, VEDANTA Institute of Medical Sciences, Navrangpura, Ahmedabad, Gujarat, India, ketankpatel20{at}hotmail.com

Atul K. Patel, MD

Infectious Diseases Clinic, VEDANTA Institute of Medical Sciences, Navrangpura, Ahmedabad, Gujarat, India

Parimal Sarda, MD

Department of Pathology, Hemato-Oncology Clinic, VEDANTA Institute of Medical Sciences, Navrangpura, Ahmedabad, Gujarat, India

Bhavin A. Shah, MD, DM

Department of Oncology, Hemato-Oncology Clinic, VEDANTA Institute of Medical Sciences, Navrangpura, Ahmedabad, Gujarat, India

Rajiv Ranjan, MBBS

Infectious Diseases Clinic, VEDANTA Institute of Medical Sciences, Navrangpura, Ahmedabad, Gujarat, India

Visceral Leishmaniasis (VL) is endemic in the Ganges and Brahmaputra plains of India. Leishmaniasis/HIV coinfection is on the rise in India and may pose a real diagnostic and therapeutic challenge. HIV-related immunosuppression increases the risk of reactivating leishmaniasis by 100 to 1000 times and it also increases the risk of drug resistant leishmaniasis. Immune reconstitution VL is not very well reported in literature. Hemophagocytosis is known to occur with various infectious agents like viruses, bacteria, and parasites, but is rare to occur with leishmaniasis. Here the authors describe a case of VL presenting as immune reconstitution disease and hemophagocytosis in an HIV infected patient coming from a nonendemic area.

Key Words: visceral leishmaniasis • HIV • immune reconstitution inflammatory syndrome • hemophagocytosis

This version was published on July 1, 2009

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 8, No. 4, 217-220 (2009)
DOI: 10.1177/1545109709337902
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