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Journal of the International Association of Physicians in AIDS Care (JIAPAC)
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Seven-Year Follow-Up on Lopinavir/ Ritonavir Monotherapy

Gerald Pierone, Jr, MD

Treasure Coast Infectious Disease Consultants, Vero Beach, Florida, Indian River Medical Center, Vero Beach, Florida, pieroneg{at}verocma.com

Jeffrey Mieras, RN

Treasure Coast Infectious Disease Consultants, Vero Beach, Florida, Indian River Medical Center, Vero Beach, Florida

Amber Martin, PharmD

Treasure Coast Infectious Disease Consultants, Vero Beach, Floriad, Indian River Medical Center, Vero Beach, Florida

Theresa Urban, PharmD

Treasure Coast Infectious Disease Consultants, Vero Beach, Florida, Indian River Medical Center, Vero Beach, Florida

Previous studies of lopinavir/ritonavir (LPV/r) monotherapy have shown that over 70% of patients achieved HIV RNA levels <500 copies/mL over a follow-up period of 48 to 96 weeks, but the long-term durability is undetermined. Herein, the authors report 2 patients that started LPV/r monotherapy after virologic failure on an NNRTIbased regimen and have been successfully treated for greater than 7 years. Both patients demonstrated long-term control of viral replication over the course of treatment, although the first patient had 3 viral load blips and the second had 1 blip under 400 copies/mL. Both patients had increases in CD4+ lymphocyte counts. The first patient from 96 cells/µL to 378 cells/µL and the second patient from 71 cells/µL to 411 cells/µL. To the authors knowledge, these 2 cases represent the longest experience with LPV/r monotherapy and provide some measure of reassurance about the durability of LPV/r for control of HIV replication.

Key Words: HIV • lopinavir/ritonavir • monotherapy

This version was published on May 1, 2009

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 8, No. 3, 191-192 (2009)
DOI: 10.1177/1545109709335752
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