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Sustained Increase of HDL Cholesterol Over a 72-Week Period in HIV-Infected Patients Exposed to an Antiretroviral Regimen Including Lopinavir/Ritonavir

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris

Karine Lacombe, MD, PhD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris, karine.lacombe{at}sat.ap-hop-paris.fr

Jean-Marie Poirier, MD, PhD

Service de pharmacologie, Assistance Publique-Hopitaux de Paris

Olivier Massot, PhD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris

Bénédicte Lefebvre, MD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris

Olivier Bouchaud, MD, PhD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris, Hôpital Avicennes, Bobigny, France

Jean-Baptiste Guiard-Schmidt, MD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Paris, France

Alvaro Martinez, MSc

Université Pierre et Marie Curie-Paris 6, INSERM UMR S 538, Paris, France, Service de biochimie - biologie moléculaire, Assistance Publique-Hôpitaux de Paris, Hopital Saint-Antoine, Paris, France

Pascale Benlian, MD, PhD

Université Pierre et Marie Curie-Paris 6, INSERM UMR S 538, Paris, France, Service de biochimie - biologie moléculaire, Assistance Publique-Hôpitaux de Paris, Hopital Saint-Antoine, Paris, France

Pierre-Marie Girard, MD, PhD

Service des maladies infectieuses et tropicales, Assistance Publique-Hôpitaux de Paris

Metabolic disorders are a major concern during antiretroviral therapy, especially for their potential to increase cardiovascular disease risk. In a multicenter, prospective study conducted in patients exposed to an antiretroviral regimen including lopinavir boosted with ritonavir, an early and sustained increase of high-density lipoprotein cholesterol was observed over a 72-week period. This increase was positively correlated with the exposure to lopinavir/ritonavir during the first 24 weeks.

Key Words: lopinavir plasma concentration • antiretroviral drug • HIV • high-density lipoprotein cholesterol • dyslipidemia

This version was published on December 1, 2008

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 7, No. 6, 311-316 (2008)
DOI: 10.1177/1545109708326088


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