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Journal of the International Association of Physicians in AIDS Care (JIAPAC)
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Possible Case of CNS Whipple's Disease in an Adolescent With AIDS

Sameer J. Patel, MD

Department of Pediatrics, Division of Pediatric Infectious Diseases, Coulumbia University Medical Center, sp2172{at}columbia.edu

Richard C. Huard, PhD

Department of Pathology, Clinical Microbiology Service, Columbia University Medical Center

Christian Keller, MD

Department of Pathology, Division of Neuropathology Columbia University Medical Center, New York, NY

Marc Foca, MD

Department of Pediatrics, Division of Pediatric Infectious Diseases, Coulumbia University Medical Center

An adolescent with HIV/AIDS presented subacutely with progressive encephalopathy, spastic quadraplegia, and diarrhea. His brain biopsy was suggestive of central nervous system Whipple's disease, a disease rarely described in HIV patients. Due to overlapping, nonspecific symptoms associated with several opportunistic infections and to the difficulty in culturing the causative organism Tropheryma whipplei, Whipple's disease may be more common than previously suspected, and it is an important consideration in patients with AIDS.

Key Words: Whipple's disease • HIV • AIDS • encephalopathy

This version was published on April 1, 2008

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 7, No. 2, 69-73 (2008)
DOI: 10.1177/1545109708315328
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