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Epstein-Barr Virus–Associated Nasopharyngeal Carcinoma and Local Polymorphic B-Cell Lymphoproliferative Disorder in a Patient With HIV DiseaseDepartment of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy, Roberto.manfredi{at}unibo.it
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy
Department of Pathology, DMCO University of Milan, S. Paolo Hospital and IRCCS Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum," S. Orsola Hospital, Bologna, Italy A rare case report of HIV-associated nasopharyngeal carcinoma concurrent with local polymorphic B-cell lymphoproliferative disorder is reported and discussed on the ground of the most recent literature evidences. Only very few reports of nasopharyngeal carcinoma have been described until now in patients infected with HIV (one case in adults), and a coexisting lymphoid cell proliferation with a concurrent role of Epstein-Barr virus in prompting both disorders was never reported to date. The relevant pathogenetic, diagnostic, and therapeutic questions raised by this infrequent intriguing association retrieved in a patient with prominent HIV-related immunodeficiency are focused on.
Key Words: nasopharyngeal carcinoma lymphoproliferative disorder Epstein-Bar virus HIV pathogenesis diagnosis management
This version was published on December
1, 2007 Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 6, No. 4,
255-259 (2007) |
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