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This version was published on September 1, 2007
Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 6, No. 3, 206-209 (2007)
DOI: 10.1177/1545109707304494

Adverse Events in HIV-Infected Persons Receiving Antiretroviral Drug Regimens in a Large Urban Slum in Nairobi, Kenya, 2003-2005

Andrea A. Kim

Global AIDS Program, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, aakim{at}cdc.gov

Lucy Wanjiku

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Doris K. Macharia

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Mary Wangai

Republic of Kenya Ministry of Health, Nairobi, Kenya

Anthony Isavwa

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Hussein Abdi

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Barbara J. Marston

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Festus Ilako

African Medical Research Foundation-Kenya, Nairobi, Kenya

Mette Kjaer

African Medical Research Foundation-Kenya, Nairobi, Kenya

Kenneth Chebet

Republic of Kenya Ministry of Health, Nairobi, Kenya

Kevin M. De Cock

Global AIDS Program, CDC-Kenya, Nairobi, Kenya

Paul J. Weidle

Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia, USA

Objective: This article describes toxicities to antiretroviral therapy (ART) among HIV-infected patients receiving care at a clinic in a large urban slum in Nairobi, Kenya. Methods: Patients were treated with nonnucleoside reverse transcriptase inhibitor-based ART and followed at scheduled intervals. Frequencies and cumulative probabilities of toxicities were calculated. Results: Among 283 patients starting ART, any and severe clinical toxicity were recorded as 65% and 6%, respectively. Cumulative probabilities for remaining free of any and severe clinical toxicities at 6, 12, and 18 months, were 0.47, 0.26, and 0.17, respectively and 0.98, 0.95, and 0.89, respectively. The probability of remaining free from elevated and grade 3 or 4 serum aminotransferase (AST) at 6, 12, and 18 months were 0.62, 0.42, and 0.21, respectively, and 0.99 at 6, 12, and 18 months. Conclusions: ART toxicities were frequent, but severe toxicities were less common. In resource-limited settings, ART toxicity should not represent a barrier to care.

Key Words: HIV • antiretroviral therapy • nonnucleoside reverse transcriptase inhibitor • toxicity • Africa


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