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Journal of the International Association of Physicians in AIDS Care (JIAPAC)
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Use of Dronabinol Improves Appetite and Reverses Weight Loss in HIV/AIDS-Infected Patients

Edwin DeJesus, MD, FACP

Orlando Immunology Center, Orlando, Florida, edejesus{at}oicorlando.com

Barry M. Rodwick, MD

Health Positive, Safety Harbor, Florida

Daniel Bowers, MD

Pacific Oaks Medical Group, Beverly Hills, California

Calvin J. Cohen, MD

Community Research Initiative of New England, Boston, Massachusetts

Daniel Pearce, DO

Altamed Health Service Corp, Los Angeles, California

Objective: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS. Methods: A retrospective chart review was conducted to analyze weight and appetite changes and nausea status in patients with HIV/AIDS who received dronabinol for 3 to 12 months from January 11, 1993, to March 17, 2003. Results: Of the 117 patients who lost weight before baseline, 63% maintained or gained weight. In patients receiving dronabinol for 1 year, the mean weight gain (± SD) was 3.7 ± 10.6 lb. The percentage of patients experiencing loss of appetite decreased significantly from 71% at baseline to 26% at 1 month (P < .001) and continued to decline throughout the trial. The percentage of patients experiencing nausea at baseline (38%) decreased consistently from week 2 on; this change from baseline was significant at month 6 (P = .031). Conclusion: When taken for 3 months to 1 year, dronabinol significantly improves appetite and reverses weight loss in patients living with HIV/AIDS.

Key Words: dronabinol • anorexia • weight loss • nausea • AIDS

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 6, No. 2, 95-100 (2007)
DOI: 10.1177/1545109707300157
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