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High Rate Multiple Drug Resistances in HIV-Infected Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Regimens in Thailand, Where Subtype A/E is Predominant

Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand; ploencha{at}kku.ac.th

Siriluck Anunnatsiri, MD

Srinagarind Hospital, Khon Kaen University, Khon Kaen

Sasisopin Kiertiburanakul, MD

Ramathibodi Hospital, Mahidol University, Bangkok

Ruengpung Sutthent, PhD

Thanomsak Anekthananon, MD

Siriraj Hospital, Mahidol University, Bangkok

Chureeratana Bowonwatanuwong, MD

Chonburi Hospital, Chonburi

Boonchai Kowadisaiburana, MD

Bamrasnaradura Institute, Nonthaburi

Khuanchai Supparatpinyo, MD

Chiang Mai University Hospital, Chiang Mai University, Chiang Mai

Manassinee Horsakulthai, MS

Srinagarind Hospital, Khon Kaen University, Khon Kaen

Sanchai Chasombat, MD

Bureau of AIDS, TB, and STI, Department of Disease Control, Ministry of Public Health, Thailand

Kiat Ruxrungtham, MD

Chulalongkorn University Hospital, Chulalongkorn University; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok

the Study Team

The prevalence of drug resistance was determined among 64 HIV-infected Thai patients who were failed while receiving nonnucleoside reverse transcriptase inhibitor (NNRTI)–based regimens. Eighty-nine percent of patients had 1 or more NNRTI mutation resistances. Almost all patients had resistance to at least 1 nucleoside reverse transcriptase inhibitor (NRTI), and 42% had multiple-NRTI resistance.

Key Words: drug resistance in Thailand • NNRTI resistance • NRTI resistance • NNRTI failure

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 5, No. 4, 152-156 (2006)
DOI: 10.1177/1545109706294288


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