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DOI: 10.1177/1545109706294288 High Rate Multiple Drug Resistances in HIV-Infected Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Regimens in Thailand, Where Subtype A/E is PredominantSrinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand; ploencha{at}kku.ac.th
Srinagarind Hospital, Khon Kaen University, Khon Kaen
Ramathibodi Hospital, Mahidol University, Bangkok
Siriraj Hospital, Mahidol University, Bangkok
Chonburi Hospital, Chonburi
Bamrasnaradura Institute, Nonthaburi
Chiang Mai University Hospital, Chiang Mai University, Chiang Mai
Srinagarind Hospital, Khon Kaen University, Khon Kaen
Bureau of AIDS, TB, and STI, Department of Disease Control, Ministry of Public Health, Thailand
Chulalongkorn University Hospital, Chulalongkorn University; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok
The prevalence of drug resistance was determined among 64 HIV-infected Thai patients who were failed while receiving nonnucleoside reverse transcriptase inhibitor (NNRTI)based regimens. Eighty-nine percent of patients had 1 or more NNRTI mutation resistances. Almost all patients had resistance to at least 1 nucleoside reverse transcriptase inhibitor (NRTI), and 42% had multiple-NRTI resistance.
Key Words: drug resistance in Thailand NNRTI resistance NRTI resistance NNRTI failure
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