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Low Absolute Neutrophil Counts in African Infants

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, apk3{at}cdc.gov

Brian Bramson, MD

Department of Medicine, University of North Carolina, Chapel Hill

Charles van der Horst, MD

Department of Medicine, University of North Carolina, Chapel Hill

Peter Kazembe, MB ChB

Kamuzu Central Hospital, Lilongwe, Malawi

Yusuf Ahmed, BM

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

Charles Chasela, BSc, DHPed

University of North Carolina Project, Lilongwe, Malawi

Mina Hosseinipour, MD

Department of Medicine, University of North Carolina, Chapel Hill, University of North Carolina Project, Lilongwe, Malawi

Rodney Knight, PhD

Department of Medicine, University of North Carolina, Chapel Hill

Lebah Lugalia

University of North Carolina Project, Lilongwe, Malawi

Gerald Tegha

University of North Carolina Project, Lilongwe, Malawi

George Joaki

University of North Carolina Project, Lilongwe, Malawi

Robert Jafali

University of North Carolina Project, Lilongwe, Malawi

Denise J. Jamieson, MD, MPH

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

UNC Project BAN Study Team

Infants of African origin have a lower normal range of absolute neutrophil counts than white infants; this fact, however, remains under appreciated by clinical researchers in the United States. During the initial stages of a clinical trial in Malawi, the authors noted an unexpectedly high number of infants with absolute neutrophil counts that would be classifiable as neutropenic using the National Institutes of Health’s Division of AIDS toxicity tables. The authors argue that the relevant Division of AIDS table does not take into account the available evidence of low absolute neutrophil counts in African infants and that a systematic collection of data from many African settings might help establish the absolute neutrophil count cutpoints to be used for defining neutropenia in African populations.

Key Words: Neutropenia • absolute neutrophil count • infants • African

Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 4, No. 3, 73-76 (2005)
DOI: 10.1177/1545109705282591


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