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HIV-1 Reverse Transcriptase Variation in Plasma and Genital Secretion of Antiretroviral-Naive Females
Uma Shanmugasundaram, PhD,
Suniti Solomon, MD,
Saravanan Shanmugam, PhD,
Kailapuri G. Murugavel, PhD,
Kumarasamy Nagalingeswaran, PhD,
Sunil S. Solomon, PhD, MPH,
Kenneth H. Mayer, MD,
and
Balakrishnan Pachamuthu, PhD*
* To whom correspondence should be addressed. E-mail: bala{at}yrgcare.org.
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Abstract |
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The reverse transcriptase (RT) enzyme of HIV type 1 (HIV-1) is largely targeted by the host immune selection pressure and would differ in the anatomical compartments, thereby having a drastic impact on viral quasi-species evolution. The HIV-1 RT region sequenced from plasma and genital secretions of 8 antiretroviral treatment (ART)-naive females was analyzed for the pattern of amino acid mutations and the ratio of synonymous and nonsynonymous substitutions to determine whether it is under different selection pressure in both the compartments. Phylogenetic and mutational analysis of the HIV-1 RT in plasma and genital secretions of HIV-1-infected ART-naive females showed limited variation likely reflecting the absence of differential selection pressure and therefore genetic variation in these compartments.
First published on October 12, 2009
Journal of the International Association of Physicians in AIDS Care (JIAPAC) 2009, doi:10.1177/1545109709347374
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