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Update on DidanosineNational Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia Didanosine (ddI) has been a cornerstone of HIV management since it was made available in October 1991. Didanosine was originally introduced as an alternative to zidovudine (ZDV) for patients who were intolerant of ZDV or experienced disease progression during ZDV monotherapy. Didanosine is now used extensively as an integral component of multidrug combination regimens in both adults and children with HIV infection, and is now available for once-daily administration in the United States, Canada, and Europe. The recently approved Videx® EC is an enteric-coated didanosine capsule dosed as one capsule, once daily. This paper provides an update of recently published studies on the use of ddI in combination anti-HIV therapy. In particular, these studies examine the rationale for the use of ddI as first-line anti-HIV therapy, and describe newer findings concerning its long-term efficacy, side effects, compliance, resistance, and once-daily use. The increased survival of HIV-infected patients is largely attributed to the introduction of the triple combination drug therapy but is probably also due to the long-term clinical efficacy of ddI.
Key Words: didanosine • combination drug therapy • treatment outcome
Journal of the International Association of Physicians in AIDS Care (JIAPAC), Vol. 1, No. 1,
15-25 (2002) |
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